The distribution of tetraphenylporphinesulfonate in the tumor-bearing rat.
نویسنده
چکیده
The distribution of tetraphenylporphinesulfonate, following its parenteral adminis tration to rats bearing the Walker carcinosarcoma, has been studied. It was found that the concentration in the tumor was greater than that in any of the other tissues studied, but several of these tissues also had appreciable concentrations. The concen tration was found to be dependent upon dose, and the distribution was affected by time following administration. Tetraphenylporphinesulfonate was found to be transported in the blood bound to the serum proteins. The concentration of this material found in the tumor was far greater than that obtained with hematoporphyrin in other studies.
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عنوان ژورنال:
- Cancer research
دوره 22 شماره
صفحات -
تاریخ انتشار 1962